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The Potential of Stem Cells in Regenerative Medicine, Diseases Therapeutics and Research

Received: 10 February 2022    Accepted: 17 March 2022    Published: 8 April 2022
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Abstract

Stem cells are a form of indistinct cells with the capability to self-renew and replicate. Stem cells originate from a single cell and differentiate into a range of cells and organs in the normal course of things. Stem cells can be used to heal damaged cells or rebuild tissues in cellular treatment. Furthermore, stem cells have advanced our knowledge of both development and disease pathogenesis. Cell lines that are particular to a disease can be produced and employed in medication research. Despite considerable advancements in stem cell biology, ethical concerns about embryonic stem cells, tumor development, and rejection limit their application. Many of these constraints, however, are being circumvented, which could lead to considerable breakthroughs in disease management. This session covers the basics of stem cells, such as their definition, origin, and classification, as well as their applications in regenerative therapy and cell therapy. Stem cells are classified as pluripotent, multipotent, totipotent, or unipotent depending on their potential, and as embryonic stem cells, adult stem cells, or induced pluripotent stem cells based on their origin. The goal of embryonic stem cells, adult stem cells, and induced pluripotent stem cells in regenerative therapy, a relatively new field of medicine, is to restore the function of specific tissue and/or organs in patients who have suffered catastrophic injuries or chronic disease conditions. The clinical relevance of stem cells in treating cancer, vision loss, diabetes, and burns has sparked a surge in scientific and medical interest in stem cells. In addition, stem cells will be explored for disease modeling and medication development, as well as stem cell and tissue banks for various research goals and future usage. In addition, the limitations of stem cell-based treatments will be investigated.

Published in Cell Biology (Volume 10, Issue 1)
DOI 10.11648/j.cb.20221001.11
Page(s) 1-15
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Cell Therapy, Regenerative Therapy, Stem Cells, Therapeutics

References
[1] Aly, R. M. Current state of stem cell-based therapies: An overview. Stem Cell Investig. 2020, 7, 8.
[2] Arno A, Smith AH, Blit PH, Shehab MA, Gauglitz GG, Jeschke MG. Stem cell therapy: a new treatment for burns? Pharmaceuticals (Basel) 2011; 4: 1355–1380.
[3] Arora V, Arora P, Munshi AK. Banking stem cells from human exfoliated deciduous teeth (SHED): saving for the future. J Clin Pediatr Dent 2009; 33: 289-94. 58.
[4] Attwood SW, Edel MJ. iPS-Cell Technology and the Problem of Genetic Instability-Can It Ever Be Safe for Clinical Use? J Clin Med 2019; 8: 288.
[5] Bai, X.; Alt, E. Myocardial regeneration potential of adipose tissue-derived stem cells. Biochem. Biophys. Res. Commun. 2010, 401, 321–326.
[6] Bartold PM, Gronthos S, Ivanovski S, et al. Tissue engineered periodontal products. J Periodontal Res 2016; 51: 1-15. 48.
[7] Beeryam JC. and List MG., Different types of stem cells and their sources, 12/11, 2017.
[8] Bloor, A. J. C.; Patel, A.; Griffin, J. E.; Gillee, M. H.; Radia, R.; Yeung, D. T.; Drier, D.; Larson, L. S.; Uenishi, G. I.; Hei, D.; et al. Production, safety and efficacy of iPSC-derived mesenchymal stromal cells in acute steroid-resistant graft versus host disease: A phase I, multicenter, open-label, dose-escalation study. Nat. Med. 2020.
[9] Cheng-Liang Zhang, Ting Huang, Bi-LI Wu, Stem cells in cancer therapy: opportunities and challenges, 8 (43): 75756–75766, 2017.
[10] Ching Liu Y., Pierre Lesimple, Raul Bukowiecki, Gizem Inak, Human disease modelling using stem cells, V. 10, Pg 573-732, 2009.
[11] Chu, D. T.; Nguyen, T. T.; Tien, N. L. B.; Tran, D. K.; Jeong, J. H.; Anh, P. G.; Thanh, V. V.; Truong, D. T.; Dinh, T. C. Recent Progress of Stem Cell Therapy in Cancer Treatment: Molecular Mechanisms and Potential Applications. Cells 2020, 9, 563.
[12] Claus, C.; Jung, M.; Hubschen, J. M. Pluripotent Stem Cell-Based Models: A Peephole into Virus Infections during Early Pregnancy. Cells 2020, 9, 542. 38.
[13] Cordeiro MM, Dong Z, Kaneko T, et al. Dental Pulp Tissue Engineering with Stem Cells from Exfoliated Deciduous Teeth. J Endod 2018; 34: 962-9.
[14] Cyranoski D. The potent effects of Japan’s stem-cell policies. Nature 2019; 573: 482-5.
[15] Denham M. Mouse Embryonic Stem Cell Derivation, and Mouse and Human Embryonic Stem Cell Culture and Differentiation as Embryoid Bodies, vol. 7, no. 4, pp. 66–75, 2005.
[16] Falanga V. Stem cells in tissue repair and regeneration, Nature Method. vol. 8, no. 10, pp. 829–831, 2012.
[17] Figueiredo-Larsen, Chiara Gregio Manuel, Samy Gobba, Tissue specific progenitor stem cells in regenerative medicine, 140 (21): 4452–4462, 2013.
[18] Fortier L. A., “Stem cells: classifications, controversies, and clinical applications,” Veterinary Surgery, vol. 34, no. 5, pp. 415– 423, 2005.
[19] Frontiers in Bioengineering and Biotechnology, vol. 3, article 169, 2015.
[20] Gaskell T, Englund MCO, Hyllner J. Human embryonic stem cells. In: Steinhoff G. editor. Regenerative Medicine - from Protocol to Patient: 2. Stem Cell Science and Technology. 3rd edition. Springer, 2016.
[21] Greggio C. F, De Franceschi, M. Figueiredo-Larsen et al., “Artificial three-dimensional niches deconstruct pancreas development in vitro,” Development, vol. 140, no. 21, pp. 4452–4462, 2019.
[22] Gubareva E. A., Sjoqvist S., Gilevich I. V. et al., “Orthotopic transplantation of a tissue engineered diaphragm in rats,” Biomaterials, vol. 77, pp. 320–335, 2016.
[23] Hanna J., Marius Wernig, Styliani Markoulaki, Chiao-Wang Sun et al, Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin, doi: 10.1126/science.1152092. Epub 2007 Dec 6.
[24] Hoffman, A.; Ziller, M.; Spengler, D. Focus on Causality in ESC/iPSC-Based Modeling of Psychiatric Disorders. Cells 2020, 9, 366.
[25] Hogan M. S., Parfitt D.-E., Zepeda-Mendoza C. J., Shen M. M, and D. L. Spector, “Transient pairing of homologous Oct 4 alleles accompanies the onset of embryonic stem cell differentiation,” Cell Stem Cell, vol. 16, no. 3, pp. 275–288, 2015.
[26] International Society of Stem Cell Research, Guidelines for Stem Cell Research and Clinical Translation, ISSCR, Illinois, USA, 2016.
[27] Issacgon G., Perez-K, ohler, J. Garrido-Gomez et al., “Evaluation of the cell viability of human Wharton’s Jelly stem cells for use in cell therapy,” Tissue Engineering Part C: Methods, vol. 18, no. 6, pp. 408–419, 2018.
[28] Jiang Z., Han Y., and Cao X., “Induced pluripotent stem cell (iPSCs) and their application in immunotherapy,” Cellular and Molecular Immunology, vol. 11, no. 1, pp. 17–24, 2018.
[29] Kimmelman, H. E. Heslop, J. Sugarman et al., “New ISSCR guidelines: clinical translation of stem cell research,” Lancet, vol. 387, no. 10032, pp. 1979–1981, 2016.
[30] Larijani B, Esfahani EN, Amini P, Nikbin B, Alimoghaddam K, Amiri S, Malekzadeh R, Yazdi NM, Ghodsi M, Dowlati Y, Sahraian MA, Ghavamzadeh A. Stem cell therapy in treatment of different diseases. Acta Medica Iranica. 2012: 79–96.
[31] Liu Q., Swistowski A, Peng J, et al. Efficient generation of functional dopaminergic neurons from human induced pluripotent stem cells under defined conditions. Stem Cells 2010; 28: 1893-904.
[32] Logan, S.; Arzua, T.; Canfifield, S. G.; Seminary, E. R.; Sison, S. L.; Ebert, A. D.; Bai, X. Studying Human Neurological Disorders Using Induced Pluripotent Stem Cells: From 2D Monolayer to 3D Organoid and Blood Brain Barrier Models. Compr. Physiol. 2019, 9, 565–611.
[33] Lorenz Carmen, Pierre Lesimple, Raul Bukowiecki, Gizem Inak, Human disease modelling using stem cells, V. 10, Pg 573-732, 2009.
[34] Ma L, Makino Y, Yamaza H, et al. Cryopreserved Dental Pulp Tissues of Exfoliated Deciduous Teeth Is a Feasible Stem Cell Resource for Regenerative Medicine. PLoS One 2012; 7: e51777.57.
[35] Magotani H. Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s disease, 2020.
[36] Mahla RS (2016). "Stem Cells Applications in Regenerative Medicine and Disease.
[37] Marks PW, Witten CM, Califf RM. Clarifying StemCell Therapy’s Benefits and Risks. N Engl J Med 2017; 376: 1007-9.
[38] McGinley LM, Kashlan ON, Bruno ES, et al. Human neural stem cell transplantation improves cognition in a murine model of Alzheimer's disease. Sci Rep 2018; 8: 14776. 26.
[39] Motamed S, Taghiabadi E, Molaei H, Sodeifi N, Hassanpour SE, Shafieyan S, Azargashb E, Farajzadeh-Vajari F, Aghdami N, Bajouri A. Cell-based skin substitutes accelerate regeneration of extensive burn wounds in rats. Am J Surg. 2017; 214: 762–769.
[40] Nakashima M, Iohara K, Murakami M, et al. Pulp regeneration by transplantation of dental pulp stem cells in pulpitis: a pilot clinical study. Stem Cell Res Ther 2017; 8: 61.
[41] Osakada F, Ikeda H, Sasai Y, Takahashi M. Stepwise differentiation of pluripotent stem cells into retinal cells. Nat Protoc. 2019; 4 (6): 811–824. doi: 10.1038/nprot.2009.51.
[42] Pagliuca FW, Millman JR, Gürtler M, et al. Generation of functional human pancreatic β cells in vitro. Cell 2014; 159: 428-39.
[43] Panopoulos AD, Ruiz S, Yi F, Herrerias A, Batchelder EM, Izpisua Belmonte JC. Rapid and highly efficient generation of induced pluripotent stem cells from human umbilical vein endothelial cells. PloS one. 2011; 6: e19743.
[44] Prentice, D. A. Adult Stem Cells. Circ. Res. 2019, 124, 837–839.
[45] Raff M (November 2003). "Adult stem cell plasticity: fact or artifact?". Annual Review of Cell and Developmental Biology. 19 (1): 1–22.
[46] Ramenzoni LL, Russo G, Moccia MD, et al. Periodontal bacterial supernatants modify differentiation, migration and inflammatory cytokine expression in human periodontal ligament stem cells. PLoS One 2019; 14: e0219181.47.
[47] Raspini G, Wolff J, Helminen M, et al. Dental Stem Cells Harvested from Third Molars Combined with Bioactive Glass Can Induce Signs of Bone Formation In Vitro. J Oral Maxillofac Res 2018; 9: e2.43.
[48] Revilla A, González C, Iriondo A, Fernández B, Prieto C, Marín C, et al. Current advances in the generation of human iPS cells: implications in cell-based regenerative medicine. J Tissue Eng Regen Med. 2016; 10: 893–907.
[49] Sagar J, Chaib B, Sales K, Winslet M, Seifalian A. Role of stem cells in cancer therapy and cancer stem cells: A review. Cancer Cell Int., 2007; 7: 9-11.
[50] Saurabh Anand and Kiminobu Sugaya, Stem Cell Approaches for Treatment of Neurodegenerative Diseases, 10.4172/2167, 2014.
[51] Schulz TC, Young HY, Agulnick AD, et al. A scalable system for production of functional pancreatic progenitors from human embryonic stem cells. PLoS One 2012; 7: e37004.
[52] Shroff G. and Gupta R., “Human embryonic stem cells in the treatment of patients with spinal cord injury,” Annals of Neurosciences, vol. 22, no. 4, pp. 208–216, 2015.
[53] Shroff G., Embryonic stem cells in renerative medicine, Vol. 6, Issue, 4, pp. 3730-3738, 2015.
[54] Siegel, RL, Miller, KD, Jemal, A. Cancer statistics, 2015. CA Cancer J Clin. 2015; 65 (1): 5–29.
[55] Sobhani, N. Khanlarkhani, M. Baazm et al., “Multipotent stem cell and current application,” Acta Medica Iranica, vol. 55, no. 1, pp. 6–23, 2017.
[56] Takahashi K. and Yamanaka S., “Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors,” Cell, vol. 126, no. 4, pp. 663–676, 2006.
[57] Takasato M. Er., P. X, Chiu H. S. et al., “Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis,” Nature, vol. 526, no. 7574, pp. 564–568, 2015.
[58] Therapeutics". International Journal of Cell Biology. 2016: 6940283. doi, 10.1155.
[59] Thomson M., Liu S. J., Zou L.-N., Smith Z., Meissner A., and S. Ramanathan, “Pluripotency factors in embryonic stem cells regulate differentiation into germ layers,” Cell, vol. 145, no. 6, pp. 875–889, 2011.
[60] Urbach A, et al. Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells. Cell Stem Cell. 2010; 6 (5): 407–11.
[61] Veatch, R. M. 1981. A Theory of Medical Ethics. New York: Basic Books.
[62] Vedantham V., “New approaches to biological pacemakers: links to sinoatrial node development,” Trends in Molecular Medicine, vol. 21, no. 12, pp. 749–761, 2015.
[63] Vegas AJ, Veiseh O, Gürtler M, et al. Long-term glycemic control using polymer-encapsulated human stem cellderived beta cells in immune-competent mice. Nat Med 2016; 22: 306-11.
[64] Verlinsky, Y., Strelchenko, N., Kukharenko, V., Rechitsky, S., Veriinsky, O., Galat.
[65] Volarevic V, Markovic BS, Gazdic M, et al. Ethical and safety issues of stem cell-based therapy. Int J Med Sci 2018; 15: 36-45.
[66] Walters, L. 2004. Human embryonic stem cell research: an intercultural perspective. Kennedy Institute of Ethics Journal. 14 (1): 3-38.
[67] Wernig M, Meissner A, Foreman R, Brambrink T, Ku M, Hochedlinger K, et al. "In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state". Nature. 448 (7151): 318–24.
[68] Wright L. S., Phillips M. J., Pinilla I., Hei D., Gamm D. M. Induced pluripotent stem cells as custom therapeutics for retinal repair: progress and rationale. Exp. Eye Res. 2014; 123: 161–172.
[69] Yamada Y, Nakamura-Yamada S, Kusano K, et al. Clinical potential and current progress of dental pulp stem cells for various systemic diseases in regenerative medicine: A concise review. Int J Mol Sci 2020; 20: 1132. 49.
[70] Yang J., Cai B., Glencer P., Li Z., Zhang X., and X. Li, “Induced pluripotent stem cells and outer retinal disease,” Stem Cells International, vol. 2016, Article ID 2850873, 6 pages, 2016.
[71] Yasui T, Mabuchi Y, Morikawa S, et al. Isolation of dental pulp stem cells with high osteogenic potential. Inflamm Regen 2017; 37: 8.
[72] Zhou S., A. Flamier, M. Abdouh et al., “Differentiation of human embryonic stem cells into cone photoreceptors through simultaneous inhibition of BMP, TGFand Wnt signaling,” Development, vol. 142, no. 19, pp. 3294–3306, 2015.
Cite This Article
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    Tamirat Salile Sada. (2022). The Potential of Stem Cells in Regenerative Medicine, Diseases Therapeutics and Research. Cell Biology, 10(1), 1-15. https://doi.org/10.11648/j.cb.20221001.11

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    Tamirat Salile Sada. The Potential of Stem Cells in Regenerative Medicine, Diseases Therapeutics and Research. Cell Biol. 2022, 10(1), 1-15. doi: 10.11648/j.cb.20221001.11

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    AMA Style

    Tamirat Salile Sada. The Potential of Stem Cells in Regenerative Medicine, Diseases Therapeutics and Research. Cell Biol. 2022;10(1):1-15. doi: 10.11648/j.cb.20221001.11

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  • @article{10.11648/j.cb.20221001.11,
      author = {Tamirat Salile Sada},
      title = {The Potential of Stem Cells in Regenerative Medicine, Diseases Therapeutics and Research},
      journal = {Cell Biology},
      volume = {10},
      number = {1},
      pages = {1-15},
      doi = {10.11648/j.cb.20221001.11},
      url = {https://doi.org/10.11648/j.cb.20221001.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cb.20221001.11},
      abstract = {Stem cells are a form of indistinct cells with the capability to self-renew and replicate. Stem cells originate from a single cell and differentiate into a range of cells and organs in the normal course of things. Stem cells can be used to heal damaged cells or rebuild tissues in cellular treatment. Furthermore, stem cells have advanced our knowledge of both development and disease pathogenesis. Cell lines that are particular to a disease can be produced and employed in medication research. Despite considerable advancements in stem cell biology, ethical concerns about embryonic stem cells, tumor development, and rejection limit their application. Many of these constraints, however, are being circumvented, which could lead to considerable breakthroughs in disease management. This session covers the basics of stem cells, such as their definition, origin, and classification, as well as their applications in regenerative therapy and cell therapy. Stem cells are classified as pluripotent, multipotent, totipotent, or unipotent depending on their potential, and as embryonic stem cells, adult stem cells, or induced pluripotent stem cells based on their origin. The goal of embryonic stem cells, adult stem cells, and induced pluripotent stem cells in regenerative therapy, a relatively new field of medicine, is to restore the function of specific tissue and/or organs in patients who have suffered catastrophic injuries or chronic disease conditions. The clinical relevance of stem cells in treating cancer, vision loss, diabetes, and burns has sparked a surge in scientific and medical interest in stem cells. In addition, stem cells will be explored for disease modeling and medication development, as well as stem cell and tissue banks for various research goals and future usage. In addition, the limitations of stem cell-based treatments will be investigated.},
     year = {2022}
    }
    

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    AU  - Tamirat Salile Sada
    Y1  - 2022/04/08
    PY  - 2022
    N1  - https://doi.org/10.11648/j.cb.20221001.11
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    T2  - Cell Biology
    JF  - Cell Biology
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    UR  - https://doi.org/10.11648/j.cb.20221001.11
    AB  - Stem cells are a form of indistinct cells with the capability to self-renew and replicate. Stem cells originate from a single cell and differentiate into a range of cells and organs in the normal course of things. Stem cells can be used to heal damaged cells or rebuild tissues in cellular treatment. Furthermore, stem cells have advanced our knowledge of both development and disease pathogenesis. Cell lines that are particular to a disease can be produced and employed in medication research. Despite considerable advancements in stem cell biology, ethical concerns about embryonic stem cells, tumor development, and rejection limit their application. Many of these constraints, however, are being circumvented, which could lead to considerable breakthroughs in disease management. This session covers the basics of stem cells, such as their definition, origin, and classification, as well as their applications in regenerative therapy and cell therapy. Stem cells are classified as pluripotent, multipotent, totipotent, or unipotent depending on their potential, and as embryonic stem cells, adult stem cells, or induced pluripotent stem cells based on their origin. The goal of embryonic stem cells, adult stem cells, and induced pluripotent stem cells in regenerative therapy, a relatively new field of medicine, is to restore the function of specific tissue and/or organs in patients who have suffered catastrophic injuries or chronic disease conditions. The clinical relevance of stem cells in treating cancer, vision loss, diabetes, and burns has sparked a surge in scientific and medical interest in stem cells. In addition, stem cells will be explored for disease modeling and medication development, as well as stem cell and tissue banks for various research goals and future usage. In addition, the limitations of stem cell-based treatments will be investigated.
    VL  - 10
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  • Institute of Biotechnology, Addis Ababa University, Addis Ababa, Ethiopia

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