Ischemic Postconditioning Attenuates Ischemia/Reperfusion-induced Injury Through Activating Inflammatory Signaling Pathways

Tianyi Su; Tian Su

doi:doi:10.11648/j.cb.20210902.12

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Ischemic Postconditioning Attenuates Ischemia/Reperfusion-induced Injury Through Activating Inflammatory Signaling Pathways

Tianyi Su, Tian Su

Published in Cell Biology (Volume 9, Issue 2)

Received: 14 July 2021 Accepted: 27 July 2021 Published: 5 August 2021

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Abstract

The role of post-treatment in protecting organ ischemia and re-perfusion damage is increasingly recognized, however, its mechanism of the action is not very clear, all in all, it still needs further research. The purpose of this experiment is to investigate whether IPO can reduce I/R-induced liver damage through inhibiting inflammatory signaling pathways in rats. Rats were randomly divided into sham, I/R, IPO and LY294002+IPO groups. The levels of AST and ALT were assessed. The expression levels of IL-1, Akt, NF-κB-P65 and TNF-α were analyzed using western blot analysis. The expression levels of ALT, AST, IL -1, TNF-α and NF-κB-P65 were significant reduction in the IPO group compared with those in the I/R group. Furthermore, the protein expression level of phosphorylated Akt was observed to be significant increase in the livers of the rats in the IPO group compared with those in the I/R group. Moreover, LY294002 was found to offset the advantages of IPO. To the best of our knowledge, this study provided the clear evidence to show that IPO significantly reduced the injury caused by I/R, and it might protect the liver from hepatic injury through activating the phosphoinositide 3-kinase pathway, which increased the expression of Akt, and inhibited the protein expression of IL-1, NF-κB-P65 and TNF-α.

Published in	Cell Biology (Volume 9, Issue 2)
DOI	10.11648/j.cb.20210902.12
Page(s)	25-30
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Ischemic Postconditioning, Inflammatory, Signaling Pathways

References

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APA Style

Tianyi Su, Tian Su. (2021). Ischemic Postconditioning Attenuates Ischemia/Reperfusion-induced Injury Through Activating Inflammatory Signaling Pathways. Cell Biology, 9(2), 25-30. https://doi.org/10.11648/j.cb.20210902.12

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ACS Style

Tianyi Su; Tian Su. Ischemic Postconditioning Attenuates Ischemia/Reperfusion-induced Injury Through Activating Inflammatory Signaling Pathways. Cell Biol. 2021, 9(2), 25-30. doi: 10.11648/j.cb.20210902.12

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AMA Style

Tianyi Su, Tian Su. Ischemic Postconditioning Attenuates Ischemia/Reperfusion-induced Injury Through Activating Inflammatory Signaling Pathways. Cell Biol. 2021;9(2):25-30. doi: 10.11648/j.cb.20210902.12

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@article{10.11648/j.cb.20210902.12,
  author = {Tianyi Su and Tian Su},
  title = {Ischemic Postconditioning Attenuates Ischemia/Reperfusion-induced Injury Through Activating Inflammatory Signaling Pathways},
  journal = {Cell Biology},
  volume = {9},
  number = {2},
  pages = {25-30},
  doi = {10.11648/j.cb.20210902.12},
  url = {https://doi.org/10.11648/j.cb.20210902.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cb.20210902.12},
  abstract = {The role of post-treatment in protecting organ ischemia and re-perfusion damage is increasingly recognized, however, its mechanism of the action is not very clear, all in all, it still needs further research. The purpose of this experiment is to investigate whether IPO can reduce I/R-induced liver damage through inhibiting inflammatory signaling pathways in rats. Rats were randomly divided into sham, I/R, IPO and LY294002+IPO groups. The levels of AST and ALT were assessed. The expression levels of IL-1, Akt, NF-κB-P65 and TNF-α were analyzed using western blot analysis. The expression levels of ALT, AST, IL -1, TNF-α and NF-κB-P65 were significant reduction in the IPO group compared with those in the I/R group. Furthermore, the protein expression level of phosphorylated Akt was observed to be significant increase in the livers of the rats in the IPO group compared with those in the I/R group. Moreover, LY294002 was found to offset the advantages of IPO. To the best of our knowledge, this study provided the clear evidence to show that IPO significantly reduced the injury caused by I/R, and it might protect the liver from hepatic injury through activating the phosphoinositide 3-kinase pathway, which increased the expression of Akt, and inhibited the protein expression of IL-1, NF-κB-P65 and TNF-α.},
 year = {2021}
}

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TY  - JOUR
T1  - Ischemic Postconditioning Attenuates Ischemia/Reperfusion-induced Injury Through Activating Inflammatory Signaling Pathways
AU  - Tianyi Su
AU  - Tian Su
Y1  - 2021/08/05
PY  - 2021
N1  - https://doi.org/10.11648/j.cb.20210902.12
DO  - 10.11648/j.cb.20210902.12
T2  - Cell Biology
JF  - Cell Biology
JO  - Cell Biology
SP  - 25
EP  - 30
PB  - Science Publishing Group
SN  - 2330-0183
UR  - https://doi.org/10.11648/j.cb.20210902.12
AB  - The role of post-treatment in protecting organ ischemia and re-perfusion damage is increasingly recognized, however, its mechanism of the action is not very clear, all in all, it still needs further research. The purpose of this experiment is to investigate whether IPO can reduce I/R-induced liver damage through inhibiting inflammatory signaling pathways in rats. Rats were randomly divided into sham, I/R, IPO and LY294002+IPO groups. The levels of AST and ALT were assessed. The expression levels of IL-1, Akt, NF-κB-P65 and TNF-α were analyzed using western blot analysis. The expression levels of ALT, AST, IL -1, TNF-α and NF-κB-P65 were significant reduction in the IPO group compared with those in the I/R group. Furthermore, the protein expression level of phosphorylated Akt was observed to be significant increase in the livers of the rats in the IPO group compared with those in the I/R group. Moreover, LY294002 was found to offset the advantages of IPO. To the best of our knowledge, this study provided the clear evidence to show that IPO significantly reduced the injury caused by I/R, and it might protect the liver from hepatic injury through activating the phosphoinositide 3-kinase pathway, which increased the expression of Akt, and inhibited the protein expression of IL-1, NF-κB-P65 and TNF-α.
VL  - 9
IS  - 2
ER  -

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Author Information

Tianyi Su

Department of Surgery, Nanan District People's Hospital, Chongqing, P. R. China
Tian Su

Department of Surgery, Chongqing Medical University, Chongqing, P. R. China

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APA Style

Tianyi Su, Tian Su. (2021). Ischemic Postconditioning Attenuates Ischemia/Reperfusion-induced Injury Through Activating Inflammatory Signaling Pathways. Cell Biology, 9(2), 25-30. https://doi.org/10.11648/j.cb.20210902.12

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ACS Style

Tianyi Su; Tian Su. Ischemic Postconditioning Attenuates Ischemia/Reperfusion-induced Injury Through Activating Inflammatory Signaling Pathways. Cell Biol. 2021, 9(2), 25-30. doi: 10.11648/j.cb.20210902.12

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AMA Style

Tianyi Su, Tian Su. Ischemic Postconditioning Attenuates Ischemia/Reperfusion-induced Injury Through Activating Inflammatory Signaling Pathways. Cell Biol. 2021;9(2):25-30. doi: 10.11648/j.cb.20210902.12

Copy | Download

@article{10.11648/j.cb.20210902.12,
  author = {Tianyi Su and Tian Su},
  title = {Ischemic Postconditioning Attenuates Ischemia/Reperfusion-induced Injury Through Activating Inflammatory Signaling Pathways},
  journal = {Cell Biology},
  volume = {9},
  number = {2},
  pages = {25-30},
  doi = {10.11648/j.cb.20210902.12},
  url = {https://doi.org/10.11648/j.cb.20210902.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.cb.20210902.12},
  abstract = {The role of post-treatment in protecting organ ischemia and re-perfusion damage is increasingly recognized, however, its mechanism of the action is not very clear, all in all, it still needs further research. The purpose of this experiment is to investigate whether IPO can reduce I/R-induced liver damage through inhibiting inflammatory signaling pathways in rats. Rats were randomly divided into sham, I/R, IPO and LY294002+IPO groups. The levels of AST and ALT were assessed. The expression levels of IL-1, Akt, NF-κB-P65 and TNF-α were analyzed using western blot analysis. The expression levels of ALT, AST, IL -1, TNF-α and NF-κB-P65 were significant reduction in the IPO group compared with those in the I/R group. Furthermore, the protein expression level of phosphorylated Akt was observed to be significant increase in the livers of the rats in the IPO group compared with those in the I/R group. Moreover, LY294002 was found to offset the advantages of IPO. To the best of our knowledge, this study provided the clear evidence to show that IPO significantly reduced the injury caused by I/R, and it might protect the liver from hepatic injury through activating the phosphoinositide 3-kinase pathway, which increased the expression of Akt, and inhibited the protein expression of IL-1, NF-κB-P65 and TNF-α.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Ischemic Postconditioning Attenuates Ischemia/Reperfusion-induced Injury Through Activating Inflammatory Signaling Pathways
AU  - Tianyi Su
AU  - Tian Su
Y1  - 2021/08/05
PY  - 2021
N1  - https://doi.org/10.11648/j.cb.20210902.12
DO  - 10.11648/j.cb.20210902.12
T2  - Cell Biology
JF  - Cell Biology
JO  - Cell Biology
SP  - 25
EP  - 30
PB  - Science Publishing Group
SN  - 2330-0183
UR  - https://doi.org/10.11648/j.cb.20210902.12
AB  - The role of post-treatment in protecting organ ischemia and re-perfusion damage is increasingly recognized, however, its mechanism of the action is not very clear, all in all, it still needs further research. The purpose of this experiment is to investigate whether IPO can reduce I/R-induced liver damage through inhibiting inflammatory signaling pathways in rats. Rats were randomly divided into sham, I/R, IPO and LY294002+IPO groups. The levels of AST and ALT were assessed. The expression levels of IL-1, Akt, NF-κB-P65 and TNF-α were analyzed using western blot analysis. The expression levels of ALT, AST, IL -1, TNF-α and NF-κB-P65 were significant reduction in the IPO group compared with those in the I/R group. Furthermore, the protein expression level of phosphorylated Akt was observed to be significant increase in the livers of the rats in the IPO group compared with those in the I/R group. Moreover, LY294002 was found to offset the advantages of IPO. To the best of our knowledge, this study provided the clear evidence to show that IPO significantly reduced the injury caused by I/R, and it might protect the liver from hepatic injury through activating the phosphoinositide 3-kinase pathway, which increased the expression of Akt, and inhibited the protein expression of IL-1, NF-κB-P65 and TNF-α.
VL  - 9
IS  - 2
ER  -

Copy | Download